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CIO WM Global Investment Office
document TEXT-001-HOUSE_OVERSIGHT_025247.txt Oct 25, 2012 House Oversight Committee — Epstein Estate Records (Nov 2025)

CIO WM Global Investment Office CIO monthly video www.ubs.com/cio-video For smartphone users: scan the code with an app like "scan" UBS CIO Monthly Extended November 2012 Published 25 October 2012 This report has been prepared by UBS AG. Please see important disclaimers and disc...

NLV-I has capital commitments of $310 million, and the Fund Managers began investing in
document IMAGES-007-HOUSE_OVERSIGHT_024030.txt House Oversight Committee — Epstein Estate Records (Nov 2025)

New Leaf Funds NLV-I has capital commitments of $310 million, and the Fund Managers began investing in mid-2005. The fund completed its new investment period in early 2008 with a portfolio of 22 companies. NLV-I has fully realized 13 investments, and there are nine active invest...

CHAPTER II Cannabis Science 101
document IMAGES-008-HOUSE_OVERSIGHT_024661.txt House Oversight Committee — Epstein Estate Records (Nov 2025)

CHAPTER II Cannabis Science 101 Caryophyllene: Caryophyllene is known for its peppery, woody and spicy smell. It is believed to have several medicinal benefits, such as antibacterial, anticancer, antifungal and anti-ischemic, and a thera- peutic application as a bronchodilator....

Portfolio Company Leverage
document IMAGES-007-HOUSE_OVERSIGHT_024076.txt House Oversight Committee — Epstein Estate Records (Nov 2025)

Portfolio Company Leverage To the extent that any investment is made in a portfolio company with a leveraged capital structure, such investment will be subject to increased exposure to adverse economic factors such as a significant rise in interest rates, a severe downturn in th...

Deployment challenges are limiting sovereign
document IMAGES-009-HOUSE_OVERSIGHT_026689.txt House Oversight Committee — Epstein Estate Records (Nov 2025)

Deployment challenges are limiting sovereign ability to match targets In previous reports, we observed sovereigns’ return gaps, driven by low interest rates and challenging targets for fixed income allocations. We have also noted how appetite for alternatives has grown as sovere...

New Leaf’s investment strategy is differentiated in the venture capital industry in terms of its
document IMAGES-007-HOUSE_OVERSIGHT_024042.txt House Oversight Committee — Epstein Estate Records (Nov 2025)

V. NEW LEAF VENTURE PARTNERS INVESTMENT STRATEGY New Leaf’s investment strategy is differentiated in the venture capital industry in terms of its sector focus, specific approaches within each sector, and the depth of experience and long-term track record that supports each eleme...

Since 2005, the Fund Managers have managed the remaining portfolio of healthcare technology
document IMAGES-007-HOUSE_OVERSIGHT_024056.txt Mar 31, 2014 House Oversight Committee — Epstein Estate Records (Nov 2025)

VII. ONGOING RELATIONSHIP WITH SPROUT FUNDS Since 2005, the Fund Managers have managed the remaining portfolio of healthcare technology investments in Sprout Capital VI, L.P., Sprout Capital VII, L.P., and Sprout Capital IX, L.P. under a Sub-Management Agreement between Credit S...

in thousands of blogs and other written forums and converts this unstructured content
document IMAGES-007-HOUSE_OVERSIGHT_024051.txt House Oversight Committee — Epstein Estate Records (Nov 2025)

in thousands of blogs and other written forums and converts this unstructured content into structured information to support better-informed decision making by patients, providers, and pharmaceutical marketing teams. e Investment Theme - Patient Engagement / Shift to Low-Cost Se...

Morgan Stanley | sesearcs NORTH AMERICA INSIGHT ~~
document IMAGES-008-HOUSE_OVERSIGHT_025583.txt House Oversight Committee — Epstein Estate Records (Nov 2025)

Morgan Stanley | sesearcs NORTH AMERICA INSIGHT ~~ Disclosure Section The information and opinions in Morgan Stanley Research were prepared by Morgan Stanley & Co. LLC, and/or Morgan Stanley C-T.V.M. S.A., and/or Morgan Stanley Mexico, Casa de Bolsa, S.A. de C.V., and/or Morgan...

The Fund Managers have been an active investor in the medical device sector across the New
document IMAGES-007-HOUSE_OVERSIGHT_024034.txt Mar 31, 2014 House Oversight Committee — Epstein Estate Records (Nov 2025)

MEDICAL DEVICES RETURNS SUMMARY: The Fund Managers have been an active investor in the medical device sector across the New Leaf and Sprout Funds. Combined, the Fund Managers have invested $371 million in 29 medical device companies, and have gross realizations of $394 million a...

Sprout Capital Healthcare Technology Portfolios
document IMAGES-007-HOUSE_OVERSIGHT_024031.txt House Oversight Committee — Epstein Estate Records (Nov 2025)

Sprout Capital Healthcare Technology Portfolios: Since 1995, members of the New Leaf team made all of the healthcare technology investments in the Sprout Funds while they were part of the investing team at the Sprout Group. The Sprout Funds were venture capital funds that were d...

New Leaf team five years ago and has made significant contributions to the NLV-II portfolio
document IMAGES-007-HOUSE_OVERSIGHT_024013.txt House Oversight Committee — Epstein Estate Records (Nov 2025)

New Leaf team five years ago and has made significant contributions to the NLV-II portfolio. Jim Niedel MD PhD has worked with the team continuously for over twelve years and will continue to be a senior member of the NLV investment team for NLV-III, but will change his status to...

Methodology Used to Calculate Net Returns Numbers for Sprout Healthcare Technology
document IMAGES-007-HOUSE_OVERSIGHT_024106.txt House Oversight Committee — Epstein Estate Records (Nov 2025)

Methodology Used to Calculate Net Returns Numbers for Sprout Healthcare Technology Portfolios Estimated net returns numbers for the managed healthcare portfolio of the Sprout funds are based on New Leaf’s calculations of synthetic net returns. The synthetic net returns for the h...

to Temporary Investments, “PIPES” and other purchases of
document IMAGES-007-HOUSE_OVERSIGHT_024059.txt House Oversight Committee — Epstein Estate Records (Nov 2025)

to Temporary Investments, “PIPES” and other purchases of securities in private placements that are not traded on a Public Securities Market at the time of such investment, “toe-hold” investments (e.g. investments that are intended to lead to a potential private or larger investme...

Top 10 US Ideas Quarterly
document TEXT-001-HOUSE_OVERSIGHT_014622.txt Jan 3, 2017 House Oversight Committee — Epstein Estate Records (Nov 2025)

Top 10 US Ideas Quarterly Q1 Top 10 Ideas Strategy Equity | 03 January 2017 Corrected Top 10 US Ideas – 1Q17 The backdrop for risk assets has changed dramatically over the past year. As Michael Hartnett pointed out, 2016 saw global interest rates fall to 5,000-year lows and the...